It is used by women to help reduce vaginal and urinary symptoms of menopause (such as vaginal dryness/burning/itching, painful urination, frequent urges to urinate). These symptoms are caused by the body making less estrogen. Estradiol vaginal gel, insert, and ring are used to treat changes in and around the vagina (eg, vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. Estradiol is a hormonal medication that comes in a variety of forms. Here’s our dosage guide for using vaginal estradiol via cream, ring, or suppository. ESTRING® (estradiol vaginal system) is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina. For Estring, carefully follow the instructions for use. If you have difficulty removing Estring, contact your healthcare provider right away. ESTRING is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina. ESTRING PROVIDES RELIEF OF LOCAL SYMPTOMS OF MENOPAUSE ONLY. Estring (estradiol vaginal ring) is a form of estrogen, a female sex hormone, used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination. ESTRING (estradiol vaginal system) is an off-white, soft, flexible ring with a center that contains 2 mg of estradiol (an estrogen hormone). ESTRING releases estradiol into the vagina in a consistent, stable manner for 90 days. Estring vaginal ring can be inserted by a physician or the patient and removed after 90 days or replaced if continuous therapy is needed. Estring contains estradiol, a form of estrogen, which is a female sex hormone that regulates many processes in the body. This product information is intended only for residents of the United States. Estring (estradiol) is a vaginal ring that reduces the symptoms of menopause like vaginal irritation, dryness or pain during sex.